Mutations in the STK11 Gene Characterize Minimal Deviation Adenocarcinoma of the Uterine Cervix
نویسندگان
چکیده
منابع مشابه
Minimal deviation adenocarcinoma of the uterine cervix: A case report
Minimal deviation adenocarcinoma (MDA) of the uterine cervix is a rare disease. The rate of misdiagnosis is relatively high and there is no standard treatment. A 58-year-old woman presented with an abnormal Pap smear revealing atypical glandular cells and vaginal mucoid discharge. Cervical biopsy revealed cervicitis and an endometrium with atypical glands and increasing mitoses. A frozen sectio...
متن کاملMinimal Deviation Endometrioid Adenocarcinoma of the Uterine Cervix - A Case Report
first described by Gusserow in 1870 as a well differentiated adenocarcinoma in which most of the glands are impossible to be distinguished from the normal endocervical mucosa, although the MDA invades deep into the cervical stroma. At first, MDA was restricted to the mucinous type, but the definition of MDA has been expanded to other cell types, including the endometrioid, clear cell and nonspe...
متن کاملMicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix
BACKGROUND MicroRNA (miRNA) expression is known to be deregulated in cervical carcinomas. However, no data is available about the miRNA expression pattern for the minimal deviation adenocarcinoma (MDA) of uterine cervix. We sought to detect deregulated miRNAs in MDA in an attempt to find the most dependable miRNA or their combinations to understand their tumorigenesis pathway and to identify di...
متن کاملDiagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature
Minimal deviation adenocarcinoma (MDA) of the uterine cervix, otherwise known as adenoma malignum, is a rare variant of cervical adenocarcinoma, which represents a diagnostic challenge in the field of gynecologic oncology, due to its benign-resembling histological characteristics. To achieve a better understanding of this disease, we present two cases of MDA: one case presented with profuse wat...
متن کامل[Adenocarcinoma of the uterine cervix].
From January 1, 1947, through December 31, 1971, 219 patients with primary adenocarcinoma of the intact uterine cervix were treated at the M.D. Anderson Hospital and Tumor Institute. Two modes of therapy were primarily used, namely, irradiationtherapy alone and irradiation therapy plus operation. The 5 year survival resultsare 83.7 per cent for patients with Stage i disease, 48.0 per cent for...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2003
ISSN: 0023-6837,1530-0307
DOI: 10.1097/01.lab.0000049821.16698.d0